BCL6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center Bcells and related lymphomas. BCL6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas and BCL6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. BCL6 has been detected immunohistochemically in follicularlymphomas, diffuse large B cell lymphomas, Burkitt’s lymphomas and in nodular, lymphocyte predominant Hodgkin’s disease.