p170 / p-Glycoprotein / MDR Ab-2 (Clone F4)

Primary Antibodies

p170 / p-Glycoprotein / MDR Ab-2 (Clone F4)

Multi-drug resistance (MDR) associated pglycoprotein (p170) causes resistance to various drugs in a number of cancer patients. It exists in a soluble and membrane associated form. Soluble P-glycoprotein is detected in extracellular fluids of cancer patients, such as malignant ascites and serum. The Mr of soluble P-glycoprotein is the same as that of membrane bound P-glycoprotein.

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Overview

Host: Mouse

Clone: F4

Isotope: IgG1

Species Reactivity: Human, Chinese Hamster. Does not react with mouse. Others-not known

Epitope: Extracellular amino terminal half This epitope is resistant to formalin fixation and periodate oxidation and is different from those of other commonly known MAbs to P-glycoprotein, such as C219, JSB-1, and MRK16, which recognize an intracellular and extracellular epitope of P-glycoprotein, respectively

Immunogen: Human and hamster drug-resistant viable cells followed by crude plasma membranes

Molecular Weight: 170kDa

Positive Control: Drug resistant cells. Kidney or breast carcinoma. MCF-7

Localization: Cell membrane

Application: IF, FC

Purification Method: Protein G chromatography

SKU	Regulatory Status	Format	Volume	Action
MS-660-P1: p170 / p-Glycoprotein/ MDR	RUO	Purified Ab with BSA and Azide	0.5 ml	Request a Quote

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