E- cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominantly in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Numerous studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis. E- cadherin is used in distinguishing LCIS from DCIS and that of ILC from IDC in indeterminate cases.