Primary Antibodies
Collagen VII Ab-1 (Clone LH7.2) Mouse Monoclonal Antibody
The product (MS-444) has been discontinued. No sub available; Please contact Customer Support with any questions.
Ab-1 shows no cross-reaction with Type I, II, III, IV, and V collagens, laminin, and fibronectin. It reacts with the basement membrane zone of stratified squamous epithelia. Ab-1 is useful in differentiating invasive from noninvasive melanoma through clear visualization of appearance and integrity of epidermal basement membrane. Ab-1 is also helpful in the identification of recessive Dystrophic Epidermolysis Bullosa (RDEB) in which Type VII collagen is defective.
Overview
Host: Mouse
Clone: LH7.2
Isotope: IgG1/ k
Species Reactivity: Human, Marmoset, Monkey, Cow, Sheep, Goat, Pig, and Guinea pig
Epitope: On non-helical (non-collagenous) C-terminal region of collagen VII and is resistant to collagenase, trypsin, pronase, neuraminidase, chondroitinase, and hyaluronidase. However, it is lost by digestion of collagen VII with pepsin
Immunogen: Insoluble fractions of human neonatal foreskin epidermal cells
Molecular Weight: 250kDa (intact) 150kDa (digested )
Positive Control: Normal skin
Localization: Epidermal basement membrane
Application: IHC, IF
Purification Method: Protein G chromatography
Pricing
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