Primary Antibodies
Epidermal Growth Factor Receptor (EGFR) Ab-3 (Clone EGFR.1)
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Overview
Host: Mouse
Clone: EGFR.1
Isotope: IgG2b/ K
Species Reactivity: Human and Horse. Does not react with mouse. Others-not known
Epitope: aa 6-273
Immunogen: A431 human epidermoid cells
Molecular Weight: 170kDa (wild type)
Positive Control: A431 cells express only the intact and not the vIII variant of EGFR. HC2 20 d2 cells express the vIII variant. In normal breast, ducts and lobules show diffuse cytoplasmicstaining
Localization: Cell membrane
Application: IHC, IP, IF, FC
Purification Method: Protein A chromatography
Products
| SKU | Regulatory Status | Format | Volume | Action |
|---|---|---|---|---|
| MS-311-B1: EGFR | RUO | Biotinylated with BSA and Azide | 0.5 ml | Request a Quote |
| MS-311-P1: EGFR | RUO | Purified Ab with BSA and Azide | 0.5 ml | Request a Quote |
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