Primary Antibodies
c-erbB-2 / HER-2 / neu Ab-2 (Clone 9G6.10)
c-erbB-2, second member (c-erbB-2/HER- 2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein.
Overview
Host: Mouse
Clone: 9G6.10
Isotope: IgG1
Species Reactivity: Human. Does not react with mouse and rat. Others-not known
Epitope: Extracellular domain
Immunogen: RAC311 cells transfected with SV40-neu construct, expressing human neu protein
Molecular Weight: 185kDa
Positive Control: SKBR-3 cells, or breast carcinomas
Localization: Cell membrane
Application: IP, IF, FC
Purification Method: Protein G chromatography
Products
| SKU | Regulatory Status | Format | Volume | Action |
|---|---|---|---|---|
| MS-229-P1: c-erbB-2 / HER-2/ neu | RUO | Purified Ab with BSA and Azide | 0.5 ml | Request a Quote |
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